Re: unbinding
PNG is also lossless to the kind of colour information that manga entails. If you want to be certain of keeping it almost exactly the same, just scan and save as 64-coloured PNG-8. 64 colours is very safe, if not overkill, since perceptually you cannot distinguish between 64 different shades of greyscale, unless you are a falcon or cat. But I can presume you are not.
TIFF is too large with no benefit. It is both slower to open, and larger.
The time I can maybe understand the use of TIFF is for the RGB coloured pages if you want to be sure not to have any loss from a PNG-8 (which you should never use) or block artifacts from a JPG; although a JPG saved with 100 quality is very unlikely to get any visual defects, especially after a resize. Unless you release your chapters in 600 dpi.
Even a PNG-24 might end up with better size than the TIFF, and still be lossless.